Optimizing the neuron-electrode interface for chronic bioelectronic interfacing
Keogh, C. (2020). "Optimizing the neuron-electrode interface for chronic bioelectronic interfacing" Neurosurgical Focus.
CV
Summary
DPhil student, Oxford Neural Interfacing, University of Oxford
I am a clinical-academic trainee in neurosurgery, currently completing an EPSRC-funded DPhil on the application of engineering techniques to the management of nervous system pathology using neuromodulation at the University of Oxford, based at the John Radcliffe Hospital.
My current work is based on detailed computational modelling of the anatomy and physiology of neural systems and their interaction with external electric fields with the aim of developing techniques for targeted electrical neuromodulation in neurological disease.
Work & Education
Education
- DPhil (Surgical Sciences), University of Oxford, 2019 - 2022
- MRCS (Membership), Royal College of Surgeons, 2019
- MB BCh BAO (Medicine), Trinity College Dublin, 2012 - 2018
- MSc (Neural Engineering), Trinity College Dublin, 2015 - 2016
Postgraduate Examinations
- October 2019 MRCS Part B
- January 2019 MRCS Part A
Work
- Clinical Research Fellow, Oxford Neural Interfacing , 2019 - 2022
- Intern (Foundation Training), Academic Track Training Programme, HSE, 2018 - 2019
Professional Affiliations
- Royal College of Surgeons, Member
- European Association of Neurosurgical Societies, Member
- European Society for Stereotactic and Functional Neurosurgery, Member
- International Functional Electrical Stimulation Society, Member
- Institute of Electrical and Electronics Engineers, Member
- IEEE Engineering in Medicine and Biology Society, Member
Publications
Functional network mapping reveals state-dependent response to IGF1 treatment in Rett Syndrome
Keogh, C. et al (2020). "Functional network mapping reveals state-dependent response to IGF1 treatment in Rett Syndrome" Brain Sciences.
Statistical modeling of cortical connectivity using non-invasive electroencephalograms
Keogh, C. et al (2019). "Statistical modeling of cortical connectivity using non-invasive electroencephalograms" JoVE.
Global perspectives on task shifting and task sharing in neurosurgery
Global Neurosurgery Survey Collaborators (2019). "Global perspectives on task shifting and task sharing in neurosurgery" World Neurosurgery: X.
Challenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives
STARSurg Collaborative (2019). "Challenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives" BMC Medical Research Methodology.
Clinical and genetic Rett Syndrome phenotypes are defined by stable electrophysiological profiles
Keogh, C. et al (2018). "Clinical and genetic Rett Syndrome phenotypes are defined by stable electrophysiological profiles" BMC Paediatrics.
Association between peri-operative angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers and acute kidney injury in major elective non-cardiac surgery: a multicentre, prospective cohort study
STARSurg Collaborative (2018). "Association between peri-operative angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers and acute kidney injury in major elective non-cardiac surgery: a multicentre, prospective cohort study" Anaesthesia.
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study
STARSurg Collaborative (2018). "Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study" BJS Open.
Awards
- European Society for Stereotactic and Functional Neurosurgery Research Award, 2021
- International Functional Electrical Stimulation Society Vodovnik Award, 2021
- Trinity College Graduate Award, 2020 & 2021
- Clarendon Scholarship, 2019
- NIHR Doctoral Award, 2019
- EPSRC Doctoral Training Award, 2019
- Trinity Whitehead Scholarship, 2019
- Oxford Medical Science Division Scholarship, 2019
- Royal Academy of Medicine in Ireland Clinical Research Medal, 2019
- World Federation of Neurosurgical Societies Young Neurosurgeon Award, 2018
- North American Neuromodulation Society Travel Award, 2018
- HSE Clinical-Academic Training Award, 2018
- HSE Spark Innovation Award, 2018
- Trinity College Surgical Society Award, 2018
- Intensive Care Society Essay Prize, 2018
- Trinity College Dublin Dean’s Leadership Award, 2017
- Dublin University Biological Society President’s Medal, 2017
- Henry Cooke Drury Research Fellowship, 2016
- Amgen Scholarship, ETH Zurich, 2015
- Trinity College Dublin Postgraduate Travel Award, 2015
- Trinity College Dublin Foundation Scholarship, 2014
- Erasmus Scholarship, Université de Nantes, 2014
- Henry Hutchinson Stewart Medical Scholarship, 2013
- John Mallet Purser Medal, 2013
- Trinity College Dublin Entrance Exhibition Award, 2012
Patents
- System and method for stimulating a nerve, automated resuscitation system; filed 2020, patent pending
Talks
Invited Talks
- Efficient representation of hand biomechanics for upper limb neuroprostheses, Restorative Surgery session, Congress of the European Society for Stereotactic and Functional Neurosurgery, Marseille 2021
- Non-invasive phrenic nerve stimulation to avoid ventilator induced diaphragm deconditioning in critical care: parameter optimisation, FES in Critical Care session, RehabWeek 2021 (online)
- Targeted bioelectronics: towards personalised neuromodulation, University Hospital Limerick, Limerick, Ireland, 2019
- Towards targeted bioelectronics: a combined biomaterials & signal analysis approach, Johns Hopkins Neurosurgical Grand Rounds, Baltimore, United States, 2017
- Stretchable electronics for next-generation neural interfaces, Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland, 2015
Oral Presentations
- The role of the Ih current on the excitability of layer five pyramidal cells, European Institute for Theoretical Neuroscience, 2021
- Computational modelling reveals feedback integration across brain areas in behaving mice, 2020 Neuromatch, Online
- Initial development and validation of an artificial intelligence based decision assistance platform for precision medicine in cortical network pathology, Royal Academy of Medicine in Ireland Conference, Dublin, Ireland 2019
- Targeted bioelectronics: towards personalised neuromodulation, National Academic Track Conference, Dublin, Ireland 2019
- Network-based biomarkers of epilepsy status using inter-ictal EEG in high-risk patients, World Federation of Neurosurgical Societies, Kuala Lumpur, Malaysia 2018
- Prediction of epilepsy status and treatment response in Rett Syndrome: a combined support vector machine – neural network method, European Society for Pediatric Neurosurgery, Bonn, Germany 2018
- Predicting developmental outcomes in extremely low birth weight infants: a statistical learning approach, Joint Meeting of the European Neonatal Societies, Venice, Italy 2018
- Modulation of auditory attention using transcranial direct current stimulation, Bioengineering in Ireland, Antrim, Northern Ireland 2017
- Simultaneous EEG-tDCS for investigating the effects of stimulation on attentional processing in humans, Neuroscience in Ireland Symposium, Dublin, Ireland 2016
Posters
- Computational biomarkers allow targeted treatment of Rett Syndrome in a trial of a novel agent, Royal Academy of Medicine in Ireland Conference, Dublin, Ireland 2019
- Cortical network activity predicts IGF-1 treatment response in Rett Syndrome, Neuropsychopharmacology, Orlando, Florida, United States 2019
- Network-based classification accurately discriminates connectivity disorder subtypes using single trial EEG, British Neuroscience Association Conference, Dublin, Ireland 2019
- Artificial intelligence based risk stratification using EEG measures in paediatric epilepsy, Congress of Neurological Surgeons, Houston, Texas, United States 2018
- Access to Parkinson’s Disease services in Ireland: an epidemiological analysis, Irish Geriatric Society Conference, Cavan, Ireland 2018
- Access to specialist Parkinson’s Disease services in Ireland: an audit of compliance with best practice guidelines, Frontiers in Neurology, Dublin, Ireland 2017
- Access to specialist Parkinson’s Disease services in Ireland: an analysis of factors associated with access to care, Frontiers in Neurology, Dublin, Ireland 2017
- Stretchable electronics for next-generation neural interfaces, Brain Repair Spring School, Cambridge, UK 2016
- Modulation of auditory attention using transcranial direct current stimulation, Bioengineering in Ireland, Galway, Ireland 2016
- Stretchable electronics for next-generation neural interfaces, Amgen Foundation Scholars’ Conference, Cambridge, UK 2015
Teaching
Service and leadership
- Fellow, Reproducible Research Oxford, 2021 - Present
- Divisonal Representative, Nuffield Department of Surgical Sciences, 2019 - Present
- Academic Committee Member, Trinity College, University of Oxford, 2019 - Present
- President, Clarendon Council, 2019 - 2020
- Founder, FutureMed Festival, HSE Ireland, 2018-2019
- National Representative, Irish Medical Organisation, 2018 - 2019
- Chairperson, Dublin University Biological Society, 2016 - 2017
- Scientific Editor, Trinity Student Medical Journal, 2015 - 2016